what is the effect of the abnormal protein on tissue function in duchenne muscular dystrophy and skeletal muscle tissue?

Lack of the dystrophin protein in muscle cells causes them to be fragile and easily damaged. DMD carriers are females who have a normal dystrophin gene on one X chromosome and an abnormal dystrophin gene on the other X chromosome. Most carriers of DMD do not themselves have signs and symptoms of the disease, but a minority do. Symptoms can range from mild skeletal muscle weakness or cardiac involvement to severe weakness or cardiac effects and can begin in childhood or adulthood.

Explanation:

this protocol provides a detailed procedure for agarose-based ip to purify and enrich the protein of interest.

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