Which of the following statements best describes the major difference between anaphase of mitosis and anaphase i of meiosis? in anaphase i, homologous pairs are separated but sister chromatids stay joined together. in anaphase, spindle fibers pull each set of sister chromatids to opposite ends of the cell. in anaphase i, sister chromatids are separated, forming a total of four haploid cells. in anaphase, tetrads of homologous pairs are separated to form four new nuclei