What happens if the reuptake transporter is blocked?

If the reuptake transporter is blocked, it would result in augmentation of conduction of nerve impulse at those synapse.

Explanation:

Reuptake is one of the method of removal of neurotransmitters from the synaptic cleft. During reuptake, neurotransmitters are actively taken back into the neurons that released them.

Blocking the neurotransmitter reuptake transporters will allow the neurotransmitters to remain in synaptic cleft for longer. Presence of neurotransmitters in synaptic cleft for increased time period would result in enhanced conduction of nerve impulse at that particular synapse.

If the re-uptake transporter is blocked, it will result in the augmentation of conduction of nerve impulse at those synapses.

Further Explanation:

Neurotransmitters are endogenous chemicals that enable neurotransmission. It is a type of chemical messenger that transmits signals across a chemical synapse, such as a neuromuscular junction, from one neuron to another "target" neuron, muscle cell, or gland cell. During reuptake, neurotransmitters are actively taken back into the neurons that released them. Reuptake is one of the methods of removal of neurotransmitters from the synaptic cleft.  

The presence of neurotransmitters in the synaptic cleft for an increased time period would result in enhanced conduction of nerve impulse at that particular synapse.Blocking the neurotransmitter reuptake transporters will allow the neurotransmitters to remain in the synaptic cleft for longer. Antidepressant drugs also bind to the serotonin transporter. Selective serotonin reuptake inhibitors (SSRIs) act primarily at the 5HT transporter protein and have limited, if any, reaction with other neurotransmitter systems. SSRIs bind to the transporter protein directly and block the reuptake process.

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Answer Details:

Grade: High School

Subject: Biology

Chapter: Neuron

Keywords:

Neurotransmitter, primarily, taken back, chemical synapse, synaptic cleft, blocking, transporter, conduction, chemical, signal.