The difference between pinocytosis and receptor-mediated endocytosis is that . Question 14 options: pinocytosis can concentrate substances from the extracellular fluid, but receptor-mediated endocytosis cannot. pinocytosis is nonselective in the molecules it brings into the cell, whereas receptor-mediated endocytosis offers more selectivity. pinocytosis brings only water molecules into the cell, but receptor-mediated endocytosis brings in other molecules as well. pinocytosis increases the surface area of the plasma membrane, whereas receptor-mediated endocytosis decreases the plasma membrane surface area.