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Biology, 12.05.2021 04:20 beyza13

Enhancerless GFP reporter constructs used in research conducted in mice contain a generic mouse gene promoter (TATA box) followed by a transcription start site and then a GFP gene cDNA. When such enhancerless reporter gene constructs are integrated into random locations in the mouse genome, about 10% of the time, high levels of tissue-specific GFP expression are detected, even though the reporter gene construct itself has no enhancer. How is this possible

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