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thrombocytopenia, which is a deficiency in blood platelets, can cause bleeding and bruising in the dermis similar to senile purpura. other possible causes include: exposure to ultraviolet rays and aging skin are common causes of senile purpura. senile purpura may also be a sign of collagen loss in the skin and bones.

during the process of dna replication, brdu can replace thymidine and incorporate into the newly synthesized dna, cell proliferation thus can be reflected in the extent of brdu incorporation.