In DNA replication, gaps between newly synthesized segments of DNA and existing segments of DNA are sealed by enzymes called , which form covalent bonds between the two segments.

In DNA replication, gaps between newly synthesized segments of DNA and existing segments of DNA are sealed by enzymes called ligases, which form covalent bonds between the two segments.

Explanation:

During DNA replication, there is a continuous strand of DNA and fragments of DNA called Okazaki fragments. The DNA ligase will join the Okazaki fragments using ATP's energy and creating a covalent bond between the phosphate of a nucleotide in an Okazaki fragment and the sugar of a nucleotide in another Okazaki fragment. As a result, there are two continuous DNA fragments.

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