Explain how the cell division of cancer cells like these are misregulated. Identify genetic and other changes that might have caused these cells to escape normal cell cycle regulation

Due to non-functioning of protein.

Explanation:

The cell division of cancer cells like these are misregulated because they can't be control by the proteins that is responsible for the control cell division. The cancer cells can multiply without any growth control factors, or growth-stimulating protein signals that control its growth. There are some proteins that is responsible for control of cell division but due to mutation that protein of substance stop working and the cancer cell grows uncontrollable.