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Biology, 10.06.2021 22:10 telonfrippp5i9i5
Explain the difference between a dominant negative mutation and haploinsufficiency at the molecular level. An enzyme, encoded by gene A, converts substrate X into product Y. Individuals with a rare dominant mutation in gene A have severe neurological symptoms. If you could purify protein A from affected and unaffected individuals, how would you determine if the symptoms were caused by a dominant negative mutation versus haploinsufficiency. In your answer, explain your experimental results.
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