Cystathioninuria can be caused by two different mutations in the enzyme cystathionase. Cystathioninuria caused by mutation 1 can be overcome by providing cells with increasing concentrations of the coenzyme pyridoxal phosphate. Which of the following statements describe the most likely changes in the binding affinities of the two mutant enzymes?
A. Both mutant enzymes have lost the ability to bind the substrates.
B. The enzyme with mutation 1 has lost the ability to bind to the substrates, whereas the enzyme with mutation 2 has lost the ability to bind to pyridoxal phosphate.
C. The enzyme with mutation 1 has decreased affinity for pyridoxal phosphate, whereas the enzyme with mutation 2 has lost the ability to bind to the substrates.
D. Both mutant enzymes have lost the ability to bind pyridoxal phosphate.
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Cystathioninuria can be caused by two different mutations in the enzyme cystathionase. Cystathioninu...
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