Quizlet: Aspirin is known to cause stomach ulcers when taken too often owing to its inhibition of COX-1, which is constitutively expressed, and the prostaglandin product signals for localized cellular housekeeping, not pain and swelling. In contrast, COX-2 is induced (produced) when, for example, you get cut or punched in the face; then its prostaglandin product signals pain and swelling. Identify the shape-based structural features and electostatics-based structural features that would lead to a selective COX-2 inhibitor to avoid the side effects of aspirin. Don't forget to consider the intracellular location of these peripheral membrane-bound enzymes.