For the numbered steps below, select the option that places them in the correct order. 1) The ribosome binds to the mRNA and uses tRNAs to translate mRNA into the corresponding amino acid polypeptide sequence. 2) The spliceosome removes introns. 3) The primary structure of the polypeptide chain undergoes hierarchical foldings to form the tertiary structure. 4) RNA polymerase binds to the promoter region of a gene and initiates transcription.

first 4, then 2, then 1, and lastly 3

Explanation:

First, RNA polymerase binds to the promoter region of a gene on the DNA and initiates transcription. Transcription is the process by which we get mRNA (coding RNA) which is used as a template for protein synthesis. Then, in transcription, the resulting mRNA undergoes modification and maturation. This  involves removal of introns, addition of 3'-poly-A tail and 5'-cap. Introns are sequences that do not code for protein and are hence removed. The structure that removes introns is the spliceosome. Thirdly, mature mRNA travels to the cytoplasm. Ribosome (composed of rRNA) binds to mRNA and tRNA to start the process of protein synthesis. The process of formation of protein is called translation. Lastly, the primary structure of protein may undergo folding to form a tertiary structure.