Which of the following would increase the rate of an enzyme-catalyzed reaction? Decreasing enzyme, decreasing substrate, decreasing cofactors
Decreasing enzyme, decreasing inhibitors, decreasing cofactors
Increasing enzyme, decreasing substrate, decreasing cofactors
Increasing enzyme, decreasing inhibitors, increasing cofactors

Increasing enzyme, decreasing inhibitors, increasing cofactors

Explanation:

Why? Well, we know that increasing how much enzyme is available is a good method to speed up the rate of an enzyme catalyzed reaction because we have MORE enzymes to deal with the substrates. We also know that cofactors are essential for widening the range of substrates an enzyme can catalyze. Cofactors also stabilize charge, so the substrate can fit into the binding site better.