Considering what you know about proteins, why does the "folding" of the protein matter?

Generally proteins are the vital growth of each human.First of all proteins is a long string of amino acids, however it can't play out its organic function until the point when this string is changed into a three-dimensional shape.This is known as folding, and once the protein has folded, it would then be able to play out its organic function.If protein can't folded it leads to many diseases.