Adisorder called osteogenesis imperfecta damages the auditory ossicles and results in hearing loss. why

One of the components of the auditory system is the malleus incus and stapes that make up the auditory ossicles. Osteogenesis Imperfacta is a genetic disorder that affects the proper formation of connective tissue in the body. 
Bones, on the one hand, are constituted by connective tissue. The disorder will consequently affect the formation and integrity of the auditory ossicles, therefore, leading to hearing loss.

Ribonuclease activity is a type of nuclease that catalyzes the degradation of rna into small components.