Enlargement of body tissue blurred vision low sperm count weight gain feeling sluggish

Main cause can be traced to problems in Anterior Pituitary gland that secretes GH, TSH, and FSH. It can branch out to Hyperthyroidism which is a lack of thyroid hormones that causes fatigue, weight gain, and vision problems. It may also be Growth Hormone problems that cause abnormal growth patterns

Iwould say overuse ( but not 100% sure ) in the u.s. we tend to overuse water by leaving it running, throwing it away, taking long showers, etc.