Patients with alzheimer's disease tend to have abnormally levels of acetylcholine and abnormally levels of glutamate.

The binding of acetylcholine to ACH receptors results in the change on membrane of the target cell. Acetylcholine is rapidly removed by enzymatic breakdown.As the brain cells of an Alzheimer patient dies, excess amount of glutamate is released.So patients with Alzheimer's disease tend to have abnormally depleted levels of acetylcholine and abnormally higher levels of glutamate.