Mitosis and binary fission are both forms of cell division that produce identical, or close to identical, daughter cells. what is a difference between these two processes? mitosis involves two rounds of divisions, whereas binary fission only involves one round of divisions. mitosis takes longer because it involves more chromosomes and is a more complicated process. binary fission involves multiple chromosomes, while mitosis only involves one circular chromosome. binary fission takes longer because prokaryotic cells are more primitive and slower than eukaryotic cells.