Assuming that coleman's hypotheses about the ob and db genes are correct, rank the mice by the amount of appetite-suppressing hormone you would expect to find circulating in their blood. place the mouse with the lowest hormone level on the left and the mouse with the highest hormone level on the right.

Lowest levels of hormone would be when ob genes are mutated

Highest levels of hormone would be when db genes are mutated.

Further Explanation:

Colemanhypothesis states that ob+ genes codes for an appetite suppressing hormone. The amount of adipose tissue determines the production of this hormone. Also, db+ genes codes for receptor of the same hormone. So, mutations in these genes might have the following effects:When ob genes are mutated, production of functional appetite suppressing hormone stops.When db genes are mutated, production of functional receptors for the same hormone stops.

So, if the mutation occurs in both the ob genes, the production of appetite suppressing hormone stops and thus, the mice would gain the highest weight.If the mutation occurs in both the db genes, there would be no receptor to respond to the hormone produced. The mice would gain fat and produce the hormone in turn. And the hormone level would be abnormally high. Thus, lowest levels of hormone would be there in the mutated ob genes and highest levels of the hormone would be in the mutated db genes.

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Answer Details:

Grade:College Biology

Subject:Genetics

Chapter:Laws of inheritance

Keywords:

Coleman hypothesis, genes, suppressed expression, functional receptors, appetite suppressing hormone, mutations, mutated gene, hormone, hormone level, abnormally high hormone levels.

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