The product of the p53 gene the product of the p53 gene slows down the rate of dna replication by interfering with the binding of dna polymerase

P53 gene is a tumor-suppressor gene that codes for a specific transcription factor that promotes the synthesis of proteins that inhibit the cell cycle. Therefore the product of the p53 gene is inhibiting the cell cycle. The gene codes for a protein that regulates the cell cycle and thus functions as a tumor suppressor. It is vital for cells in multicellular organisms to suppress cancer or tumors.

Closing a ring restricts the rotation around individual car bon carbon bonds hope it will you !