Irreversible nerve damage may be caused by excessive intake of supplements.

The answer is the vitamin B 6 supplement can cause irreversible nerve damage. Taking too many vitamins can cause also a toxic effect on our body.  Too much vitamin B6 can also cause oversensitivity to sunlight, which can lead to skin rashes and numbness, as well as nausea, vomiting, abdominal pain, loss of appetite, and abnormal liver function.

the sphincter muscles at the end of the digestive tract is the anus.