In their mechanism of action, a difference between lipid-soluble and water-soluble hormones is that

In their mechanism of action, a difference between lipid-soluble and water-soluble hormones is that lipid-soluble hormones diffuse into the cell's plasma membrane to access protein receptors, while water-soluble hormones bind to protein receptors on the plasma membrane without diffusion.

Examples of lipid-soluble hormones are steroids. Examples of water-soluble hormones are polypeptides.

Mass is the amount of matter in an object.  weight is the measurement of the pull of gravity on an object.  say for example, you travel to the moon which has a different gravitational field compared to the gravitational field of earth. (gravitational fields: earth = 1, moon = 0.165)  now when you are on the moon, the pull of gravity on you is different than on the earth. and as weight is the measurement of the pull of gravity on an object, that means yes, your weight can and will change on the moon.  however, on the moon, on earth or even on jupiter, the amount of mass inside of you remains the same. meaning your physical mass remains constant.  in conclusion it is possible for your weight to change as your mass remains constant.