Asteady-state plasma concentration of 25 mg/l v by iv infusion to healthy volunteers (average weight, 75 kg) at a rate of 7.5 mg/kg/hr for 6 hours. calculate the total body clearance of this drug. a. 12.5 l/hr b. 22.5 l/hr c. 42.5 l/hr d. 62.5 l/hr was measured when a drug was given

The correct answer is option B.

Explanation:

Concentration of a  steady-state plasma ,= 25 mg/L

Weight of the volunteer =75 kg

Rate of infusion = 7.5 mg/kg hr

Concentration of steady-state plasma in 75 kg weight body:

Total body clearance of this drug:

The total body clearance of this drug is 22.5 L/hr.

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