Agood transition-state analog:
a) binds covalently to the enzyme.
b) binds to the enzyme more tightly than the substrate.
c) binds very weakly to the enzyme. is too unstable to isolate.
d)must be alos i entica to the substrate.
e) must be almost identical to the substrate

A) binds covalently to the enzyme

Explanation:

The transition state is the point of a reaction where greater activation energy is needed.

To produce a good transition state (with lower activation energy). When the enzyme binds to the substrate so that thermal energy (heat is the most commonly used energy source) favors breakdown of reactions and decreases the amount of energy required.

When the molecule absorbs the amount of energy needed to reach the transition state, it can carry out the rest of the reaction.