Glycolysis is the process by which energy is harvested from glucose by living things. several of the reactions of glycolysis are thermodynamically unfavorable, nonspontaneous, but proceed when they are coupled with other reactions. a. pi+glucose⟶glucose−6−phosphate+h2oδ =3.30 kcal/mol b. pi+fructose−6−phosphate⟶fructose−1, 6−bisphosphate+h2oδ=3.90 kcal/mol c. atp+h2o⟶adp+piδ=−7.30 kcal/mol