It is important not to mix r-22 and r-410a refrigerants in the same container because:
a. the mixture may be impossible to reclaim.
b. the mixture will explode.
c. the mixture is corrosive.
d. they use different oils.

It is not important not to mix R-22 and R-401A refrigerants in the same container because:
d. they use different oil.
The Freon in both systems are essentially the same but the oils in each system are not compatible which will render the mixture of the two systems useless.