Diffusion of uric acid in protein solution and binding uric acid (a) at 37oc is diffusing in an aqueous solution of proteins (p) containing 8.2 g protein/100 ml solution. uric acid binds to the proteins, and over the range of concentrations present, 1.0 g mol of acid binds to the proteins for every 3.0 g mol of total acid present in the solution. the diffusivity dab of uric acid in water is 1.21 x 10-5 cm2/s and dp = 0.091 x 10-5 cm2/s.
a. assuming no binding, predict the ratio dap/dab due only to blockage effects.
b. assuming blockage plus binding effects, predict the ratio dap/dab. compare this with the experimental value for dap/dab of 0.616.
c. predict the flux in g uric acid/scm2 for a concentration of acid of 0.05 g/l at point (1) and 0 g/l at point (2) a distance 1.5 µm away.