The drug molecules bind the protein in a 1: 1 ratio to form a drug-protein complex. the protein concentration in aqueous solution at 25 ∘c is 1.60×10−6 m . drug a is introduced into the protein solution at an initial concentration of 2.00×10−6m. drug b is introduced into a separate, identical protein solution at an initial concentration of 2.00×10−6m. at equilibrium, the drug a-protein solution has an a-protein complex concentration of 1.00×10−6m, and the drug b solution has a b-protein complex concentration of 1.40×10−6m. a. calculate the kc value for the a-protein binding reaction. b. calculate the kc value for the b-protein binding reaction. c. assuming that the drug that binds more strongly will be more effective, which drug is the better choice for further research?

a. kc = 1,67x10⁶

b. kc = 1,17x10⁷

c. Drug B is the better choice.

Explanation:

The bind of drug-protein is described as:

Protein + Drug ⇄ Drug-protein

Where kc is:

kc = [Drug-protein] / [Protein] [Drug] (1)

a. For A, the equilibrium concentration of each specie is:

[Protein]: 1,60x10⁻⁶M - x

[Drug]: 2,00x10⁻⁶M - x

[Drug-protein]: x = 1,00x10⁻⁶M

-Where x is reaction coordinate-

Thus:

[Protein]: 1,60x10⁻⁶M - 1,00x10⁻⁶M = 0,60x10⁻⁶M

[Drug]: 2,00x10⁻⁶M - 1,00x10⁻⁶M = 1,00x10⁻⁶M

Replacing in (1):

kc = [1,00x10⁻⁶] / [1,00x10⁻⁶] [0,60x10⁻⁶]

kc = 1,67x10⁶

b. For B:

[Protein]: 1,60x10⁻⁶M - x

[Drug]: 2,00x10⁻⁶M - x

[Drug-protein]: x = 1,40x10⁻⁶M

-Where x is reaction coordinate-

Thus:

[Protein]: 1,60x10⁻⁶M - 1,40x10⁻⁶M = 0,20x10⁻⁶M

[Drug]: 2,00x10⁻⁶M - 1,40x10⁻⁶M = 0,60x10⁻⁶M

Replacing in (1):

kc = [1,40x10⁻⁶] / [0,20x10⁻⁶] [0,60x10⁻⁶]

kc = 1,17x10⁷

c. The drug with the bigger kc will be the more effective because will be the drug that binds more strongly with the protein. Thus, drug B is the better choice.

I hope it helps!

answer: c.

explanation:

the ozone layer acts as a filter for the shorter wavelength and highly hazardous ultraviolet radiation (uvr) from the sun, protecting life on earth from its potentially harmful effects. when the sky is clear, there is an inverse relationship between stratospheric ozone and solar uvr measured at the earth's surface.