The following compound has been found effective in treating pain and inflammation (j. med chem. 2007, 4222). which sequence correctly ranks each carbonyl group in order of increasing reactivity toward nucleophilic addition?

The following compound has been found effective in treating pain and inflammation (J. Med. Chem. 2007, 4222). Which sequence correctly ranks each carbonyl group in order of increasing reactivity toward nucleophilic addition?

A) 1 < 2 < 3

B) 2 < 3 < 1

C) 3 < 1 < 2

D) 1 < 3 < 2

The rate of nucleophilic attack of carbonyl compounds is 2<3 <1.

Option B

Nucleophilic attack is explained as the attack of an electron rich radical to a carbonyl compound like aldehyde or a ketone. A nucleophile has a high electron density, so it searches for a electropositive atom where it can donate a portion of its electron density and become stable.

A carbonyl compound is a hybridized carbon atom with a double bonded oxygen atom in it. The oxygen atom pulls a huge portion of electron density from carbon being very electropositive.

In a ketone, there are two factors that make it less likely to undergo a nucleophilic attack than aldehyde. Firstly, the steric hindrance of two carbon groups being attached with the carbonyl carbon makes it harder for the nucleophile to approach. Secondly, the electron push by the carbon groups attached makes the carbonyl carbon a bit less electropositive than the aldehyde one. So aldehydes are more reactive towards a nucleophilic addition reaction.

the formula for the conversion of temperature from degree celsius to kelvin is:

the sample of water at is converted to kelvin temperature by using the above formula as:

on comparing the two samples of water at or we can say that at and at respectively. the difference between the temperatures of two samples of water is:

hence, one can say that the sample of water at is greater than the sample of water at by .