G What is the effect of type 2 diabetes (T2D) on pentose phosphate pathway (PPP) flux? T2D results in high basal levels of insulin, which leads to an increase PPP flux. T2D prevents an increase in PPP flux in response to elevated levels of blood glucose. T2D facilitates an increase in PPP flux in response to elevated levels of blood glucose. T2D has no effect on the PPP.

The effect of Type 2 Diabetes (T2D) on pentose phosphate pathway (PPP) flux is that T2D facilitates an increase in PPP flux in response to elevated levels of blood glucose

Explanation:

Type 2 Diabetes is a heterogeneous disorder with a complex etiology that develops in response to genetic and environmental influences. Both insulin resistance and abnormal insulin secretion occurs in Type 2 Diabetes. The effect of this disorder can lead to hyperglycemia

(excess glucose in the blood) which can cause nephrological damage, neurological damage (through generation of reactive oxygen species) and cardiovascular damage.

Pentose Phosphate Pathway is one of the metabolic pathways through which the body produces nicotinamide adenine dinucleotide phosphate (NADPH) in the brain cells to prevent oxidative stress caused by elevated glucose levels in type 2 Diabetic patients.

Therefore in Type 2 diabetes the major defence mechanism against reactive oxygen species generated due to increased blood glucose is to increase pentose phosphate pathway (PPP) flux to prevent oxidative stress. I hope this helps, thanks.