Labetalol, a β‑blocker antagonist of epinephrine and norepinephrine, is commonly used in treating high blood pressure. Labetalol can be synthesized from a primary amine and an epoxide. Using the starting materials given, identify the curved arrows to complete the mechanism for the synthesis of Labetalol. The general base (:B) will be used for proton transfers. Step 1: Identify the curved arrows for the first step.

he uptake of drugs from the intestine is often strongly influenced by diffusion. for example, consider a water-insoluble steroid for treating inflammation that is solubilized in aggregates of detergent molecules, called micelles. these micelles, aggregates of 80 soap molecules, have a molecular weight of 24,000, a diameter of 2.6 nm, and a charge of -27. the positively charge ions (counterions) in this system are na".