Thiamine (vitamin B1) deficiency diseases have a lower prevalence now than in the past. However, they are seen as beriberi in some developing regions and in regions of crisis, and as Wernicke–Korsakoff syndrome in some alcoholics. One type of beriberi causes neurological symptoms such as weakness, fatigue, and loss of sensations. What is a possible explanation for these symptoms? A. Thiamine is necessary for gluconeogenesis.
B. Hexokinase requires thiamine.
C. Coenzymes of the pentose phosphate pathway require thiamine as a precursor.
D. Thiamine is a precursor to the cofactor for succinyl coenzyme A synthetase.
E. The brain uses glucose, metabolized in glycolysis and the citric acid cycle, as its main energy source.