In the stomach, gastric acid decreases the pH to 1 - 2 to denature proteins through disruption of ionization and hydrogen bonding. The protease in the stomach, pepsin, is a member of the aspartate protease superfamily that uses two aspartate residues in the active site for acid-base catalysis of the peptide bond. Why can they not use histidine like chymotrypsin
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In the stomach, gastric acid decreases the pH to 1 - 2 to denature proteins through disruption of io...
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