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Chemistry, 18.02.2021 21:00 riverviewfarm2133

Arsenate (AsO43-) is structurally and chemically similar to inorganic phosphate (PO43-), and many enzymes that act on phosphate will also use arsenate as a substrate if it is available. However, unlike phosphates, organic compounds of arsenate are kinetically unstable. For example, acyl phosphates (such as 1,3-bisphosphoglycerate) require an enzyme to catalyze phosphate hydrolysis on a biologically relevant timescale, but acyl arsenates hydrolyze almost instantaneously in water without an enzyme. a) Predict the effect on the net reaction catalyzed by glyceraldehyde 3-phosphate dehydrogenase if phosphate were replaced by arsenate.
b) Write a balanced overall equation for the conversion of glucose to pyruvate in the presence of ATP, ADP, NAD+, and arsenate.
c) Arsenate is extremely toxic to most organisms. Based on your answers above, explain why.

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Arsenate (AsO43-) is structurally and chemically similar to inorganic phosphate (PO43-), and many en...
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