Compound A has potent antifungal activity in a cell-free system but has poor activity in mice. (a) Write the equation for the chemical equilibrium of compound A (pKa1 ~10) in an aqueous medium at physiological pH (~ 7.2). (b) Explain why compound A is not effective in mice based on the equilibrium in (a). (c) Explain why compound B could be more effective in mice than compound A

Write a hypothesis that answers the lesson question, “while observing a chemical reaction, how can you tell which reactant is limiting? ” hypothesis: if a substance is the limiting reactant, then . . because . .

Straightforward questions answered in the powerpoint slidesreaction: heating the starting materials under refluxwhat does it mean to heat under reflux? why do we choose water as the reflux solvent? what are boiling chips used for? why do we put a condenser on top of the reaction? why do we add heat and let the reaction stir for 30 minutes? why do we add sulfuric acid to the reaction after it cools as opposed to when it’s still hot? separation: filtration of precipitatewhy don’t we do an aqueous and organic extraction in the separatory funnel? why do you rinse the salicylic acid on the filter with ice cold water? purification: recrystallization of salicylic acid (no hot filtration needed)what is the difference in the amount of room temperature water vs. boiling water needed to dissolve the salicylic acid (assume a 1.2 gram yield of salicylic acid)? remember, in the lab if you need x ml of boiling water to dissolve a solid, then you should add a little more (definitely no more than 1.5 times the theoretical amount) to ensure it doesn’t recrystallize prematurely.analysis: melting point of salicylic acidwhat can you conclude if the melting point of the salicylic acid you just synthesized is 152-155oc and the 1: 1 mix of your product and “synthetic” salicylic acid is 151-154oc?

Need what is special about water as a compound? how does water regulate climate? what drives water evaporation?   why is the water vapor fresh water when it rises from the ocean? why might freshwater in the form of snow take longer to enter the water cycle again than liquid precipitation?   what is an aquifer? what role do people play in the water cycle? plz just answer as many as you can ! thx if you !