Which factors would negatively impact the bodies digestive system

Sugar – it is heating, sticky and toxic to the body in big doses

Lack of sleep – your body needs adequate rest to rejuvenate all organs so they can perform their intended roles

Over-eating – this can send your body into shutdown mode and put excess stress on your organs

Alcohol – both poisonous and toxic to the body, too much alcohol damages the body internally which is evident externally

Cold food and drinks – can create stagnation in the digestive system, slowing down the digestive process considerably

Emotions – anger/upset/frustration – all will affect one or more of your organs. Try and control what you can and let go of what you can’t

Processed foods – they contain foreign properties that are literally indigestible by the human body

Pandadol/nuerofen – contain chemicals that will alleviate pains and complaints temporarily, yet will leave a trail of destruction. Try natural remedies instead

Anti-biotics – whilst they kill bacteria and bugs – they also kill your insides! Follow up a round of anti-biotics with some gut nourishing foods

Over-exercise – will deplete your Qi and deplete your digestive strength. Exercise is fantastic in decent doses – not extremes. Are there issues in your life that you are avoiding and using exercise as a distraction from?

I only listed 10 examples for you because you didn't put any more detail on a specific number or answer.