Simple mail transfer protocol, smtp, is the protocol that handles on a server.
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Simple Mail Transfer Protocol, SMTP, is the protocol that handles outgoing email on a server.

Explanation:

There are different protocols for network communication, to set standards for different devices and applications to standardize the functionality of different devices and applications of network. SMTP is also a protocol that is used to handle the functionality of server in terms of outgoing emails from server. As named Simple mail transfer protocol (SMTP), it is clear that it is used for the handling of outgoing mails from client to the server. The server will further send the email to its destination.

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