Why weren’t opioids commonly used to treat pain until more recently?

What is tomas paine's central claim in this excerpt

What do you think is the greatest invention that you use today? explain in 4 sentences

Ineed ideas for this essay something easy that i can do does anyone have any ideas on what i should write on for this 100 points ! write a procedural essay with media that is 1 ½–2 pages in length. clearly state your topic, and include all steps necessary to complete the procedure. you will submit your prewriting and planning documents along with your essay.