Of these four words, which one is most likely to have a negative flavor or connotation?
a. confuse
b. meander
c. harangue
d. distract

First, let us define each word with their dictionary definitions:  

Confuse is making a person not certain or unable to understand onto something.
Meander is a ‘winding path or course’ (e.g. a river or a road) Harangue is a speech which is forceful or angry
Distract is causing someone ‘to stop thinking about or paying attention’ onto something or someone  

With the words and their meaning, the word that is most likely to have a negative flavor or connotation is letter C: Harangue.    

What do you mean determine? answer in comment section.