Drug abuse is characterized by:
the taking of any drug in a manner that necessitates regular usage
the taking of any drug in a manner that can cause social anxiety or antisocial behavior
the taking of any drug in a manner that can cause psychological or physical dependence
the taking of any drug in a manner that allows the abuser to maintain an aspect of personal 6

The answer is The Taking of any drug in a manner that can cause Psychological or physical dependence

That's when we become an addict.  Drug abuse is a serious problem that affect almost every community. Many resulted in death. Often time, the victims of drug abuse have a deep underlying unsatisfaction  in some areas of their live and do it to relief the unsatisfaction

Is that a negative 22 or a positive?

What you should re write your question it doesn’t make sense