What would the patient’s response to a normal drug does that because of genetic variation in an enzyme that prepares the drug found lamination results in blood drug level that is below a minimum effective concentration

Because without physical activity, the body has extra "energy" if you will, and so when it is time for bed you are not tired, so you end up staying up all night. also there is probably an effect on your internal clock, which messes with your melatonin production which goes hand in hand with your sleep cycle