Hat are the symptoms and long-term complications of genital human papillomavirus (hpv)? most people with hpv never develop symptoms, but sometimes the infection can develop into genital warts, cervical cancer, or other genital cancers. many people with hpv have few or no symptoms, but sometimes the infection spreads to cause serious issues with the nervous system or circulatory system. symptoms include fever, swollen glands, headaches, and fatigue; when the infection is left untreated, it can cause serious issues like cancer and even stroke. symptoms include joint pain, headaches, and abdominal pain; when the infection is left untreated, it can lead to serious issues like heart disease or cancer.