A52-year-old man with hypertension associated with recent unexplained weight loss presents with fever, malaise, and gradual onset of pain and weakness of his leg muscles for the past month. physical examination reveals a mottled reticular pattern overlying portions of both calves and an area of ulceration with surrounding induration on the left lateral malleolus. initial laboratory results reveal mild normochromic anemia, leukocytosis, and elevation of c-reactive protein, bun, and creatinine. which of the following is the most appropriate diagnostic evaluation to confirm the suspected diagnosis? (a) hla-b27 typing(b) rheumatoid factor(c) mri of sacroiliac joints(d) antinuclear antibodies test(e) tissue biopsy of area of induration