Acauliflower-like growth with foul-smelling discharges seen during an otoscopic exam of the left ear of an 8-year-old boy with a history of chronic otitis media. the tympanic membrane and ossicles are not visible, and the patient seems to be having difficulty hearing the nurse practitioner's instructions. which with the following conditions is best described?
(a) chronic perforation of the tympanic membrane with secondary bacterial infection.
(b) chronic mastoiditis.
(c) cholesteatoma.
(d) cancer of the middle ear.

Adouble-blinded trial for a new indication is conducted under an ind comparing two (2) marketed drugs, at twice the approved prescribed doses. on day 2, subject 603 had difficulty breathing. although it was life-threatening initially, subject 603 was treated and discharged directly from the emergency department after complete recovery. on day 5, subject 20 had a headache, which led to hospitalization and required blood pressure lowering medications. these episodes cannot be explained on the basis of the pharmacological property of either drug or the subjects' medical histories. the investigator would submit an sae report for