Phenomenon of declining physiological effects of taking a drug after sustained use is referred to

Drug tolerance.

Explanation:

Drug tolerance occurs when an individual has taken drugs at a certain dosage continuously, causing its effects to decrease over time. Thus, to create the same effects, the individual must increase their dosage.

Unfortunately, a side effect from doing this is the possibility of drug dependence or addiction. However, it is possible manage the drug use responsibly to avoid drug tolerance by taking drug holidays - when an individual chooses to not take his or her drugs to decrease the risk of tolerance.

a progressive heart disease that affects pumping action of the heart muscles.

answer; philip zimbardo;