1. a 43-year-old man has had a cough and fever for the past 2 months.. a transbronchial lung biopsy is performed, yielding a specimen with the microscopic appearance shows granulomas. which of the following chemical mediators is most important in the pathogenesis of this lesion? a bradykinin b complement c5a c interferon-v d nitric oxidee prostaglandins 34 2. an 8-year-old girl has had difficulty swallowing for the past day. on examination, her pharynx is swollen and erythematous with an overlying yellow exudate. laboratory studies show neutrophilia. streptococcus pyogenes (group a streptococcus) is cultured from her pharynx. which of the following substances is most likely to increase in response to pyrogens released by this organism? a hageman factor b immunoglobulin e c interleukin-12 (il-12) d nitric oxide e prostaglandins 3. a 41 -year-old man has had a severe headache for the past 2 days. on examination, his temperature is 39.2 0 lumbar puncture is performed, and the cerebrospinal fluid obtained has a wbc count of 910/ mm3 with 94% neutrophils and 6% lymphocytes. which of the following substances is the most likely mediator for the fever observed in this man? a bradykinin b histamine c leukotriene b4 d nitric oxide tnf