Hemolytic disease of the newborn is most likely when an Rh mother has previously given birth to an Rh infant and is now pregnant with an Rh fetus.

negative, positive, positive

Explanation:

Hemolytic disease of the newborn is most likely when an Rh NEGATIVE mother has previously given birth to an Rh POSITIVE infant and is now pregnant with an Rh POSITIVE fetus.

 The correct answer is :  Hemolytic disease of the newborn occurs frequently when an NEGATIVE Rh mother has a baby with a POSITIVE Rh father and if the baby's Rh factor is POSITIVE like her father's, it may be inconvenient if the red blood cells Baby cross with mother Rh negative.

Hemolytic disease of the newborn occurs when the baby's red blood cells break down at a rapid rate, also called fetal erythroblastosis.