The enzyme phosphofructokinase (PFK) catalyzes a key step in glycolysis. About 10% of Springer spaniels suffer from canine PFK deficiency. Given its critical role in glycolysis, which of the following conditions would be a likely consequence for dogs afflicted with this disorder?
They would be lethargic and readily tire from exercise.

The correct answer is that they would be lethargic and readily tire from exercise.

Explanation:

In glycolysis, the Phosphofructokinase (PFK) catalyzes the ATP-dependent phosphorylation to convert fructose-6-phosphate into fructose 1,6-bisphosphate and ADP.  it is one of the key regulatory of glycolysis which helps in producing energy. A PFK deficiency would make the afflicted dogs to  be lethargic and readily tire from exercise. This is because little or no energy is produced in the body.