Glucose transporters for brain cells

The main glucose transporters in the brain are Glut1 and Glut3. Of these, Glut1 exists in two isoforms of different molecular weights. ... Another feature of Glut1 is its uneven distribution between the cytoplasm and the luminal and the abluminal membranes of the endothelial cells, as demonstrated by electron microscopy.

Glucose, the major fuel in the brain, is transported across the cell membranes by facilitated diffusion mediated by glucose transporter proteins. Essentially two types of glucose transporters are localized in the membranes of brain endothelial cells, astrocytes, and neurons.

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