A 55‐year‐old woman with a headache explains to the clinician that she has had headaches before,
but this one is unusual because of some new symptoms. Which of the following symptoms would
prompt an immediate investigation?

a) The patient lost her glasses.
b) The headache comes and goes.
c) The headache is similar in nature to prior ones she has had for decades but more
severe.
d) The patient also has developed fever and night sweats and thinks she lost some
weight.
e) The patient had a car accident and minor head trauma about 3 months ago.